the Anticoagulation source
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Welcome to, The Anticoagulation Information Source, an Internet site designed for physicians and other health care personnel who want information about anticoagulation, coagulation, and therapeutic perspectives in anticoagulation therapy. Anticoagulation therapy is used for the treatment and prevention of a variety of thromboembolic disorders, but is also used for therapeutic applications including extracorporeal circulation, cardiopulmonary bypass, and surgical and other procedures including cardiac catheterization and percutaneous interventions. Heparin and its derivatives are the most widely used pharmacologic agents for these purposes. Heparin is also used
for the initial treatment of venous thromboembolism, acute coronary syndromes including myocardial infarction, and hemodialysis.

The development of low molecular weight heparins (LMWHs) has simplified the prevention and treatment of thrombotic disorders because these agents are administered by subcutaneous injection once or twice daily without laboratory monitoring. Other types of antithrombotic and anticoagulant treatment have become available or are under clinical development, including antiplatelet drugs, snake venoms, direct and indirect thrombin inhibitors, activated protein C, antithrombin III, recombinant hirudin, and bivalirudin as examples.

Because of the pivotal role of anticoagulation in cardiovascular disease, surgery, critical care, trauma, perioperative medicine, and hematology, therapeutic approaches to anticoagulation are important. Further a broad spectrum of novel anticoagulants have assumed a pivotal role in clinical medicine, yet at the same time present the potential for bleeding. This site provides links to the resources available regarding these important issues on the Internet.

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